ABSTRACT
Introduction: Uterine myomas incidence is variable asmost of the patients are asymptomatic but most commonclinical feature which makes women seek their treatment aremenorrhagia and iron deficiency anaemia leading to chronicfatigue. Study aimed to compare the efficacy of UPA andmifepristone in medical management of uterine fibroids insymptomatic patients of reproductive age group.Material and methods: A prospective randomizedobservational study was carried out, in women with single ormultiple uterine leiomyoma. Exclusion criteria: severe anemia,using any hormonal therapy, with suspected carcinomas orwith adnexal masses. 100 patients were randomly allocatedto two subgroups; group A receiving 5 mg UPA and groupB receiving 25 mg Mifepristone daily, for 13 weeks. PBACwas used to assess menstrual blood loss and Likert scorefor other symptoms. Baseline variables: uterine size andvolume, Myoma size and volume, number, hemoglobin, liverfunction tests were noted and reassessed at 1, 3 and 6 months.Endometrial sampling was done initially and at the end tostudy.Results: Mean fibroid volume reduction was 35.23% in groupA and 33.45% after 13 weeks’ treatment in group B. Meanreduction in menorrhagia: 84% in group A and 52.5% in groupB. 91% cases experienced amenorrhoea in group A and 72%in group B.Conclusion: UPA 5mg was better at achieving significantreduction in menorrhagia and achieving amenorrhoeic state ascompared to Mifepristone.
ABSTRACT
Introduction: Breast carcinoma is one of the leading causes of mortality and morbidity in females. This study was undertaken with the aims and objectives to look into the spectrum of various gross and microscopic histomorphological factors of invasive breast carcinoma. Material and methods: This is a retrospective study, only patients diagnosed with Invasive breast carcinoma-NST from 2007-2015 (8years) were included. MRM specimen’s gross and microscopic finding were collected and studied. Results: Total 257 cases were studied; maximum patients were in fifth decade, multiparous and from middle socio-economic status. Left sided carcinoma was seen in 59% cases and 41% were in UOQ. Nipple-areola was found normal in 63.2% cases and retracted in 37.6% patients. Similarly overlying skin was normal in 67.3% cases, dimpling and peau-d-orange was present in 11.3% and 9.5% respectively. ER/PR positive was found in 44.7% and negative in 49.8% while HER2 was found negative in 70.8% cases. Conclusion: in developing countries patients invariably presents with advance stages of breast carcinoma with dimpling, peau-d-orange of skin, nipple retraction and ulceration. In majority of patients tumour sizes is invariably more than 2 cm and already have positive axillary lymph nodes, tumour emboli and majority have negative ER/PR